Low Frequency Ultrasound

FDA Approval and Tests

They work hard and get a medical device FDA 510(k) cleared for wound cleansing and debridement.

Researchers at the Mayo Clinic evaluated the technology and quickly noticed a powerful wound-cleansing effect, prompting deeper analysis. Electron microscopy revealed something unexpected: low-frequency sound waves were capable of destroying several of the most dangerous antibiotic-resistant bacteria.

Use of Noncontact Low-Frequency Ultrasound in the Treatment of Chronic Foot and Leg Ulcerations: A 51-Patient Analysis
Steven J. Kavros, DPM; Erik C. Schenck, MPT — Journal of the American Podiatric Medical Association (Vol. 97, No. 2) .

"It is clear there is cell wall destruction of the bacteria after the application of noncontact low frequency ultrasound therapy. Further clinical and basic science investigations using this technology are warranted."

A follow-up study was conducted in 2010 at Winston-Salem State University with Eliaz's new device, The Qoustic Wound Therapy System. The Effects of Low-Frequency Ultrasound (35 kHz) on Methicillin-Resistant Staphylococcus aureus (MRSA) In Vitro - Teresa Conner-Kerr, PT, PhD, CWS, CLT — Wound Management & Prevention (Vol. 56, Issue 5).

Conclusions: In vitro, sound waves: 1) cause direct damage to bacterial cell walls, 2) alter the genetic code of bacteria, making them less virulent, and 3) decrease antibiotic resistance, making bacteria more susceptible to therapeutic agents.

The mission: To validate, develop, and advance this technology, integrating it into new devices and targeting additional diseases and conditions. If successful, they could move medicine forward.

The Next Medical Revolution

A New Age

The rise of artificial intelligence. A new era of space exploration. Gene-editing tools like CRISPR. Recent scientific breakthroughs have turned the once unthinkable into reality. We are entering a new age. This website introduces another remarkable advancement: sound-wave technology. Unlike diagnostic ultrasound —which simply generates images of the body — this therapeutic technology may be able to treat and heal a wide range of disease states. Imagine a new way to destroy harmful organisms, stimulate cell growth, and accelerate healing.

Overview

This site provides the following:

A description of what low-frequency ultrasound is and how it works.
A general overview of the scientific literature surrounding low-frequency ultrasound, describing what could be possible in medicine
An introduction to the principal scientists who have developed a proprietary technology platform utilizing low-frequency ultrasound.
An overview of 10 different markets that can be targeted rapidly
A list of our patents, FDA-approved device, and examples of some working prototypes
A summary of the technology and its scope

You can also access specific areas by clicking the links below:

What is Low Frequency Ultrasound and How is it Different

Diagnostic Technology Versus Therapeutic Technology

Most people are familiar with ultrasound as a diagnostic tool, commonly used to create images of the inside of the body. A typical example is the prenatal sonogram, which helps evaluate a baby’s growth and development before birth. This form of ultrasound uses high-frequency sound waves and has been a trusted medical technology for decades.

Low-frequency ultrasound is different. Instead of capturing images or aiding diagnosis, these lower-frequency sound waves may someday be able to treat and heal medical conditions.

Early research is promising and suggests that these sound waves may generate powerful therapeutic effects, including:

Destroying dangerous organisms (including drug-resistant bacteria in vitro)
Accelerating healing
Promoting cell growth
Providing pain relief
Influencing blood circulation (such as reducing or slowing bleeding)
Enhancing and energizing pharmaceutical drug delivery

How can such powerful energy be produced, contained, and directed safely? The answer lies in the delivery system.

How Does it Work - Create, Contain and Deliver Energy

Microbubbles

A new class of device can generate, contain, and deliver ultrasound energy using microscopic bubbles and acoustic streaming. When these bubbles reach their target and collapse, they release brief but highly concentrated bursts of energy. Historically, this technology has been limited by one major challenge: controlling the bubbles. If a bubble collapses too soon, the system can’t deliver enough ultrasound energy to be effective. Our scientists have developed a method to stabilize these bubbles and maintain their energy until the precise moment of release—a breakthrough known as stable cavitation.

Advancing this technology further could unlock a wide range of applications, from minimally invasive surgeries and transdermal drug delivery to gene transport, wound care, and more. Learn more. To explore the science behind stable cavitation, click here and here.

But imagine taking it a step further: What if we could harness this technology to combat antimicrobial resistance?

DESTROY ANTIBIOTIC RESISTANCE BACTERIA WITH SOUND WAVES?

MRSA

Scanning and transmission electron micrographs of methicillin-resistant Staphylococcus aureus during the control and experimental periods (× 40,000). Journal of the American Podiatric Medical Association • Vol 97 • No 2 • March/April 2007

VRE

Scanning and transmission electron micrographs of vancomycin-resistant enterococci during the control and experimental periods (× 40,000). Journal of the American Podiatric Medical Association • Vol 97 • No 2 • March/April 2007

P. aeruginosa

Scanning and transmission electron micrographs of Pseudomonas aeruginosa during the control and experimental periods (× 40,000). Journal of the American Podiatric Medical Association • Vol 97 • No 2 • March/April 2007

S. aureus

Scanning electron micrographs of Staphylococcus aureus during the control and experimental periods (× 40,000). Journal of the American Podiatric Medical Association • Vol 97 • No 2 • March/April 2007

The Qoustic Wound Therapy System

Medical device directs focused ultrasound energy to clean chronic wounds, and has been used safely on patients for many years. What if a pivot were possible? What if we went from cleaning to killing bacteria? From clean to kill to cure.

Great Discoveries Often Go Unnoticed For Years

Penicillin was ignored for 13 years but would go on to change the course of history

In the summer of 1928, a young Scottish physician named Alexander Fleming was in such a rush to go on vacation that he accidentally left a stack of dirty petri dishes in his laboratory sink. The dishes were smeared with dangerous bacteria. When Dr. Fleming returned from his vacation, he found something astonishing. One of the petri dishes was dotted with bacteria everywhere except one spot where some mold had been growing. The area around it was clear, as if protected by an unseen barrier. Upon closer inspection, Dr. Fleming realized that the mold had secreted a liquid that killed several strands of the bacteria. This finding was ignored for 13 years, hidden in plain view. It wasn’t until 1941 that this extraordinary finding led to the creation of the world’s first antibiotic, penicillin. This discovery changed the course of history.

Review of the Scientific Literature

Other Treatments for Cancer

Ultrasound selectively damages cancer cells when tuned to correct frequencies. Learn More. “If you can hit cancer cells with the right frequency, inducing harmonic resonance, you can selectively damage those cells.” The principle behind harmonic resonance is not unlike the opera singer who can break a glass with her voice. Learn More

Low-frequency ultrasound combined with microbubbles is a promising method for tumor therapy. Learn More

Tumors partially destroyed with sound don't come back. Microbubbles within the targeted tissues rapidly expand and collapse. These violent but extremely localized mechanical stresses kill cancer cells and break up the tumor’s structure. Learn More

Enhances T cell recruitment - Local administration of a plasmid and microbubbles, coupled with image-guided low-intensity ultrasound, provides a safe and effective method to create a T cell-inflamed tumor. This technology was used to produce an anticancer cytokine and consequently recruit efficacious immune cells at both the local and distant tumor sites. Learn More

Combination therapy with low-frequency ultrasound irradiation and radiofrequency ablation as a synergistic treatment for pancreatic cancer. Learn more

Controlling Blood Flow

Other Treatments for Cancer

Low frequency ultrasound (LFU) can speed up, slow down, and temporarily stop blood flow. LFU has a stimulatory effect on microcirculation, mainly due to improved oxygenation. Learn More. Increased skin blood flow during low intensity vibration in human participants Learn More

Promoting Cell Growth

Drug and Gene Delivery System

Promoting Cell Growth

Low-frequency ultrasound can influence proliferation and differentiation of odontoblast-like cells. Learn More

Ultrasound induces cellular responses that may be beneficial to wound healing. Learn More

Pain Management

Drug and Gene Delivery System

Promoting Cell Growth

Focused ultrasound technology is opening new scenarios in the field of pain management, including noninvasively predicting the outcome of ablative procedures and obtaining acute pain relief through reversible conduction blocks. Learn More

Drug and Gene Delivery System

Low-frequency ultrasound is typically used in transdermal drug transport and gene delivery. Learn more here, here, and here.

Kidney Stone Destruction

Drug and Gene Delivery System

A burst of ultrasound waves can break up kidney stones in 10 minutes. Learn More

Robotics

Kidney Stone Destruction

Accelerate Healing

Low-frequency ultrasound has captured the attention of researchers in different areas, particularly robotics, in applications with remote and proximity sensors. Learn More

Accelerate Healing

Kidney Stone Destruction

Accelerate Healing

Low‑frequency ultrasound treatment promotes the repair of various injuries and may accelerate wound healing. Learn More

Ultrasound debridement stimulates wound healing. Learn More

Healing occurs at a faster rate than with standard wound care alone. Learn More

Low-frequency ultrasound improved the rate of healing in chronic wounds Learn More

Beauty and Skin Rejuvenation

Food – Safety and Quality Control

Low-intensity, low-frequency ultrasound is increasingly used for noninvasive, external body contouring as an alternative to liposuction or laser treatments. Learn More

Ultrasound skin tightening - facial and body rejuvenation Learn More.

The benefit of combined radiofrequency and ultrasound is that it enhances surgical and nonsurgical outcomes for the face and neck. Learn More

Food – Safety and Quality Control

Utilizing low or high frequencies for the ultrasonic transducer has greatly benefited analyzing, modifying, and guaranteeing food quality (safety and quality control). Learn More

Increasing Vaccine Production

Food – Safety and Quality Control

Increasing Vaccine Production

Ultrasound waves can increase cell permeability, which, in turn, can enhance nutrient/waste exchange, thus leading to enhanced vaccine production. This finding is very meaningful in either shortening vaccine production time or increasing the yield of proteins for use as vaccines. Learn More

Industrial Applications

Water Purification and Treatment

Low frequency ultrasound may have many industrial and commercial applications as well because it can be used with liquids, gases, and fluids to:

Treat, sterilize, and degrade matter
Separate, segregate, and extract different matter.
Induce chemical reactions and increase the efficacy of other chemicals (like chlorine, bromine, and ozone).
Clean and deodorize

Imagine low-frequency ultrasound being used for water treatment. Ultrasound is an advanced oxidation technology that has demonstrated its capacity to degrade different types of organic molecules due to the generation of cavitation bubbles or cavities that promote the generation of radicals. Learn More

Mechanical biofilm disruption from ultrasound. Learn More

Reducing bacterial biofilm with ultrasound technology. Learn More

Increasing Fuel Efficiency

Water Purification and Treatment

Feasibility of low frequency ultrasound for water removal from crude oil emulsions. Ultrasound could be considered a promising technology for industrial crude oil treatment, water removal, and improved efficiency. Learn More Here, here, and here.

Our Story

Pursuing the American Dream

Two Russian scientists, unknown to one another, leave the former Soviet Union and immigrate to the United States to pursue the American Dream. Both rose to leadership in the medtech space and co-founded separate companies. In a chance encounter, they meet, and friendships quickly form. They eventually discuss starting a company together, one that revolves around a new disruptive technology, low-frequency ultrasound. Dr. Babaev tells Michael Afremov, "I have discovered a phenomenon in physics." Michael Afremov believes in him and funds two startup companies, Bacoustics and Arobella Medical.

Dr. Eliaz Babaev

Born in Azerbaijan, a region devastated by war and destruction over many generations, Dr. Eliaz Babaev earned three PhDs and taught at prestigious universities throughout the Soviet Union. He rises to leadership in a new disruptive science involving sound waves. He brings his knowledge to the New World and leaves communism behind forever. Co-founder of Celleration Inc. (former CTO and CEO). Dr. Babaev has more than 40+ years of expertise in Non-Imaging Medical Ultrasound. Learn More.

Michael Afremov

During World War 2, a young woman named Bella (Rubashkin) Afremov survived the 900-day Siege of Leningrad that claimed the lives of 800,000 civilians. Years later, she and her husband brought their son Michael to the United States, where his engineering skills and sharp mind allowed him to become a leader and disruptor in his field. He would co-found AGA Medical and co-invent the Amplatz Septal Occluder Device, a groundbreaking medical device to repair heart defects. Learn More

Summary - Changing Medicine Forever

Disruptive Technology with a Broad Range of Applications

As a review of the scientific literature demonstrates, recent breakthroughs in sonochemistry (applying sound energy) have made a wide range of procedures possible that were unthinkable before. Breakthroughs may now be possible in general surgery, oncology, cardiology, orthopedics, wound care, vaccine development, anti-aging, and pain management. There are also industrial applications (fuel efficiency, water purification, and more). If validated, these advancements would revolutionize medicine as we know it. The only real question is: which company has the vision first and takes the lead?

Become a Market Leader with this Technology Platform

Disruptive Technology with a Broad Range of Applications

This technology platform is a foundation. It provides a technical architecture for creating, launching, and operating various medical devices and more. It will require investment but has enormous potential for accelerating growth, creating value, and saving lives. It will allow the right company to innovate, advance new technologies, and create new markets.

The Advisory Team

Senator Rudy Boschwitz

Rudy Boschwitz is a former United States Senator from Minnesota. He is also a former United States Ambassador to the United Nations Commission on Human Rights. He was President George H.W. Bush's emissary to Ethiopia in 1991. His mission resulted in Operation Solomon, the rescue of the small Black Jewish community of Ethiopia and their dramatic airlift to Israel. The negotiations also helped cause a simultaneous end to the decades-long civil war in Ethiopia. In a Rose Garden ceremony in June 1991, President Bush awarded Senator Boschwitz the Citizen's Medal for his achievements in the Horn of Africa. Boschwitz attended Johns Hopkins University and New York University, where he received his law degree. He has served on the boards of many organizations, including the Chicago Mercantile Exchange, the American Cancer Society, Twin City Federal Financial Corporation, the American-Israeli Public Affairs Committee, IDT Corporation, and the Friends of the World Food Program. He also served on the Board of Directors of the Jewish Institute for National Security Affairs; has been an AIPAC Board Member; and is a member of the Council on Foreign Relations. Learn More.

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Blake Vanderhyde, Esq

Senator Rudy Boschwitz

Blake Vanderhyde, Esq., is the President of Vanderhyde Consulting, Inc. He focuses on advancing technologies, creating new markets, and disrupting existing ones. His expertise centers around strategic thinking, accelerating growth, and developing actionable plans for success in a rapidly changing world. He is also the Founder of Vanderhyde Law. He has been recognized in Minnesota Law and Politics and SuperLawyers. Blake graduated Summa Cum Laude from Saint Cloud State University in Minnesota, and the William Mitchell College of Law, where he was a member of the Law Review. He is admitted to state and federal court and has been recognized by various organizations, including Super Lawyers and Minnesota Law and Politics Who’s Who. Past and/or current memberships include: American Association for Justice, Minnesota Association for Justice, Minnesota State Bar Association, Hennepin County Bar Association, Delta Theta Phi Law Fraternity International, and the American Inns of Court, Minnesota – Douglas K. Amdahl Inn. Learn More.

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