Cardiovascular

---

United States Patent 8241324.  The present invention relates to the use of a low frequency ultrasonic device for the delivery and activation of collagen based foam sealants to a human and/or animal patient for sealing puncture wounds in vascular tissues. The ultrasonic vascular closure device comprises an ultrasonic generator, an ultrasound transducer, a chamber containing a foam sealant, a transducer tip, a radiation surface, an orifice located at the distal end of the chamber. The foam sealant is ejected into a puncture wound and activated with ultrasonic waves emitting from the radiation surface. The ultrasonic waves induce vibrations within the foam sealant, slightly warming the foam sealants to assist the rapid sealing the puncture. The ultrasonic waves also provide and anesthetic effect for the pain and discomfort from the puncture site. 

United States Patent 7896539. Ultrasound methods and apparatus for mixing two or more different liquids are disclosed. The ultrasound methods and apparatus may mix varied components including drugs, polymers, and coatings for application to a variety of medical apparatus surfaces. The apparatus and technique can generate a proper mixture which is uninterruptedly/continuously delivered to the surface of the medical apparatus. The apparatus may include specific ultrasound transducer/tip configurations which may allow for the mixing of different liquids in a mixing camera located inside of the vibrating tip. The apparatus and methods of the present invention may mix different drugs, applying them to stent surface using different effects like ultrasound cavitation and radiation forces. Furthermore, the disclosed methods and apparatus may generate a mixture and may deliver a targeted, gentle, highly controllable dispensation of continuous liquid spray which can reduce the loss of expensive pharmaceuticals.  

United States Patent 8050752.  The present invention relates to a method of treating lumens, cavities, and tissues of the body with a liquid delivered with the use of ultrasound. Delivering a liquid with the use of ultrasound may be accomplished by utilizing a device comprising an ultrasound transducer, an ultrasound horn, a channel running at least partially through said horn, and a dampening grommet at the distal end of the horn (hereafter called the “delivery device”). The delivery device may further comprise a liquid supply emptying into said channel. Subjecting liquids within the horn of the delivery device to ultrasonic energy accelerates the liquid, thereby creating a higher velocity, low pressure liquid stream. Consequently, the method of the present invention enables the treatment of maladies deep within lumens, cavities, and tissues of the body. The method of the present invention may also be used for douching and/or cleaning lumens, cavities, and tissues of the body. 

United States Patent 7896855.  A method of treating infected wounds utilizing ultrasonic vibrations to mix different materials together as to create a therapeutic combination is disclosed. The materials are mixed by passing them through an ultrasound horn vibrating in resonance, having an internal chamber. As the materials pass through the internal chamber, ultrasonic vibrations emanating from and/or echoing off the various walls of the chamber mix the materials into a potentially therapeutic combination. Ultrasonic vibrations emanating from the radiation surface of the horn may be used to spray the created therapeutic combination onto the area of the body to be treated.  

United States Patent 7896854.  A method of treating areas of the body utilizing ultrasonic vibrations to mix different materials together as to create a therapeutic combination is disclosed. The materials are mixed by passing them through an ultrasound horn vibrating in resonance, having an internal chamber. As the materials pass through the internal chamber, ultrasonic vibrations emanating from and/or echoing off the various walls of the chamber mix the materials into a potentially therapeutic combination. Ultrasonic vibrations emanating from the radiation surface of the horn may be used to spray the created therapeutic combination onto the area of the body to be treated. 

United States Patent 7901388.  A method of treating areas of the body utilizing ultrasonic vibrations to mix different materials together as to create a therapeutic combination is disclosed. The materials are mixed by passing them through an ultrasound horn vibrating in resonance, having an internal chamber. As the materials pass through the internal chamber, ultrasonic vibrations emanating from and/or echoing off the various walls of the chamber mix the materials into a potentially therapeutic combination. Ultrasonic vibrations emanating from the radiation surface of the horn may be used to spray the created therapeutic combination onto the area of the body to be treated. 

United States Patent 7846341.  The present invention relates to a method of utilizing ultrasonic waves emitted into a fluid to treat the fluid, matter within the fluid, and/or organisms within the fluid in a variety of manners such as, but not limited to, cleaning objects within the fluid, sterilizing the fluid and/or objects within it, separating bonded matter within the fluid, segregating matter within the fluid into discrete laminas, killing organisms within the fluid, inactivating organisms within the fluid, extracting matter from organisms within the fluid, extracting matter from other matter within the fluid, inducing chemical reactions within the fluid, and/or converting toxic matter within the fluid into a less toxic state. The method of the present invention comprises the steps of flowing the fluid to be treated, which may contain matter and/or organisms to be treated, through an object or plurality of objects such as, but not limited to a pipe, emptying the fluid flowing through the first object into an second object or plurality of second objects such as, but not limited to, a tank, wherein each second object possesses a cross-sectional area larger than the opening between the first objects and second objects, emitting ultrasonic waves into the fluid that are not parallel to the primary flow of fluid through the second objects as it flows through the second objects, establishing laminar flow in the fluid as the fluid flows through the second objects, and collecting the fluid in a third object or plurality of third objects such as, but not limited to, pipes. 

United States Patent 8689728.   The present invention is directed towards the holding of medical devices during manufacture to enable the application of therapeutic and/or protective coatings. More specifically, the present invention provides medical device holders that securely retain stents and other medical devices during the application of a coating while minimizing compressive and tensile forces applied to the stents. The invention avoids disruptions to coating quality due to holder blockage during coating deposition. The invention discloses an improved device containing a mandrel and frame that may improve coating uniformity by eliminating shadowing from the frame of the medical device holder when applying coatings to stents and other medical devices. 

United States Patent 7785277.  A removable applicator nozzle for use in treating a wound is provided. The removable applicator nozzle includes a nozzle, a valve and a cup. The nozzle includes a proximal portion, a distal opening and a valve interface. The proximal portion of the nozzle is engageable with a portion of a transducer of an ultrasound wound therapy device. The distal opening of the nozzle allows at least a portion of a tip of the transducer to pass there through. The valve is engageable with the valve interface of the nozzle and the valve selectively allows fluid to flow therethrough. The cup includes an aperture and a puncturing device. The aperture is engageable with the valve and the puncturing device is able to puncture a bottle that is inserted on the cup. Fluid flows from the bottle, through the aperture and the valve and onto a tip of the transducer. The fluid is then moved to the distal opening of the nozzle by a vacuum effect.